3 questions for...

Martin Zielke

Groupleader

As a doctor at the Institute of Pathology at UMG and head of the CAIMed junior research group ‘Collaborative Development and Validation of AI Models,’ I move between diagnostics and AI research on a daily basis. What drives me is the question of how we can bring AI into pathology in a way that truly supports doctors – reliably, comprehensibly and clinically proven. I am involved in both the cross-location validation of image analysis systems and novel approaches such as agent-based assistance systems and AI-supported biomarkers. In addition to academic research, my time in the health tech industry has also shaped me – it has shown me that good AI must not only be scientifically convincing, but also work in practice. I don't see AI as a substitute for medical expertise, but as an intelligent companion alongside diagnostics.

1.

You work as a doctor in pathology and also lead a CAIMed research group. How do clinical practice and AI research complement each other in your daily work?

My clinical work shows me every day where AI can create real added value – but also where the hurdles lie. AI that delivers impressive results on paper but cannot be replicated in everyday clinical practice or integrated into existing processes will not be used. My dual role allows me to derive research questions directly from clinical needs while at the same time applying the high quality standards that apply in clinical routine. AI must be measured by the same standards as any other diagnostic method: reproducibility, transparency and clinical validation.

2.

Your group is engaged in the collaborative development and validation of AI models. Why is this collaborative approach so crucial in a medical context?

Imagine an AI model being trained at a single location. It learns the local conditions - specific colourings, specific scanners, specific tissue preparations. At another location, the same model may then deliver completely different results. That is why cross-location collaboration is not a nice-to-have, but a basic requirement for reliable medical AI. If we want AI results in pathology to become relevant for therapy – for example, in the field of companion diagnostics - then we must develop, test and evaluate transparently together from the outset.

3.

Looking ahead, how do you think AI will change everyday clinical work in pathology over the next ten years?

I am convinced that in ten years' time we will see a fundamentally different pathology. Intelligent assistance systems will accompany entire diagnostic workflows in the future – from the preliminary analysis of digitised tissue sections to recommendations for further examinations. You can imagine it as a very well-informed colleague who thinks along with you and prepares things, but deliberately leaves the final decision to the human being. Pathologists will not be replaced, but will grow into a more supervisory role thanks to AI. However, the path to get there is challenging: we need models that can explain their recommendations, solid validation standards and clear regulatory rules. If we succeed, AI will not only make pathology more efficient, precise and accessible, but will also give it a completely new role at the heart of personalised medicine.